Heterologous boosting with third dose of coronavirus disease recombinant subunit vaccine increases neutralizing antibodies and T cell immunity against different severe acute respiratory syndrome coronavirus 2 variants코로나바이러스 질병 재조합 소단위 백신의 세 번째 용량으로 이종 부스팅은 다양한 중증 급성 호흡기 증후군 코로나바이러스 2 변이체에 대한 중화 항체 및 T 세포 면역을 증가시킵니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-RBD IgG anti-S booster vaccination CD4+ T cell components composite pattern coronavirus coronavirus disease COVID-19 COVID-19 vaccinations COVID-19 vaccine dose effective epitope Epitopes evaluated Evidence help Heterologous heterologous boosting homologous Humoral immunity Immune escape Immunity immunization strategy immunological in some inactivated Inactivated vaccine increase magnitude NAb NAbs natural infection Neutralizing Neutralizing antibodies neutralizing antibody neutralizing capacity omicron pandemic prime-boost strategy produced RBD IgG respiratory subunit Subunit vaccine Subunit vaccine. T cell T cell response T cells titre vaccination Vaccination strategies Vaccination strategy Vaccine Vaccine-induced immunity variant variants of concern waned [DOI] 10.1080/22221751.2022.2048969 PMC 바로가기 [Article Type] Article
Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors선택적인 SARS-CoV/SARS-CoV-2 파파인 유사 프로테아제 억제제의 설계 및 개발을 위한 특권적인 백본인 Chalcone-amideReview Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus amide antiviral immune responses backbone binding carbon caused chalcone Chalcone amide (N-benzylbenzamide) complex Compound coronavirus COVID-19 COVID-19 pandemic Critical crystal structure effort functional Genetic Host immune responses in some increase Infection inhibitor inhibitors inhibitory potency introduced maturation methyl group Papain Papain-like protease Papain-like protease (PLpro) performed PLPro polyproteins protease Protein Regulation Replication reported Research SAR SARS-CoV SARS-CoV-2 Screening selective shown similarity Structure therapeutic agent therapeutic agents Treatment treatment of COVID-19 understanding unique X-ray X-ray crystal structure. [DOI] 10.1016/j.ejmech.2022.114572 PMC 바로가기 [Article Type] Review
“Lymphocyte * Neutrophil” count decreased in SARS-CoV-2 Omicron patients in Shanghai with no significant change in CRP and SAAArticle Published on 2022-10-012022-11-16 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 변종, [키워드] all subject Analysis analyzed AUC Blood can be used CBC changes changes in Clinical data collected contrary correlated CRP cutoff value Diagnosis diagnostic differential diagnosis EOS excluded Fever had no in some inflammatory indicator lymphocyte neutrophil NLR not significantly different omicron Omicron. Patient patients patients with SARS-CoV-2 PCT positive Previous studies prognosis of patients SAA SARS-CoV-2 selected Sensitivity and specificity Shanghai significantly significantly higher significantly lower the SARS-CoV-2 Toxicity variant was selected WBC while [DOI] 10.1002/jcla.24671 PMC 바로가기
A systematic review and meta-analysis of the IgA seroprevalence in COVID-19 patients: Is there a role for IgA in COVID-19 diagnosis or severity?COVID-19 환자의 IgA 혈청 유병률에 대한 체계적인 검토 및 메타 분석: COVID-19 진단 또는 중증도에서 IgA의 역할이 있습니까?Meta-Analysis Published on 2022-10-012022-09-11 Journal: Microbiological research [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody association asymptomatic patients Biomarker caused coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 disease determine diagnostic diagnostic test diagnostic tests disease Efficacy Health health problems Humoral response humoral responses IgA Immunity in some include Infection manuscript Meta-analysis Mild observé Patient problems produced Research respiratory SARS-CoV-2 SARS-CoV-2 PCR Seroprevalence severe acute respiratory syndrome Coronavirus Severe patient severe patients severity Susceptibility. symptomatic systematic review Vaccines [DOI] 10.1016/j.micres.2022.127105 PMC 바로가기 [Article Type] Meta-Analysis
Potential pitfalls in analysing a SARS-CoV-2 RT-PCR assay and how to standardise data interpretationSARS-CoV-2 RT-PCR 분석 및 데이터 해석을 표준화하는 방법 분석의 잠재적 함정Article Published on 2022-10-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition analysed Applied Biosystem Audit automated baseline Baseline threshold carried complex data interpretation determine Diagnostics.ai Frequency implementation in some increase in Interpretation introduced investigated Laboratory manual intervention Patient PCR positive result Potential processed produced provide Real-time PCR real-time RT-PCR relative Relative threshold RT-PCR RT-PCR kit RT-PCR kits SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2. solution tested thermocyclers threshold time-consuming virus detection was determined [DOI] 10.1016/j.jviromet.2022.114589 PMC 바로가기 [Article Type] Article
Population level SARS-CoV-2 fecal shedding rates determined via wastewater-based epidemiology폐수 기반 역학을 통해 결정된 인구 수준 SARS-CoV-2 배설물 배출율Article Published on 2022-09-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] average Community Community demographics Concentration condition COVID-19 COVID-19 disease COVID-19 pandemic delta variant demographics disease Epidemiology Ethnicity Factor fecal Fecal shedding feces finding in some infected individuals involved log median age occurred Outbreaks pandemic Population predominant provided Rate remained SARS-CoV-2 SARS-CoV-2 RNA significantly increased unique vaccination variant variants virus concentration Virus concentrations wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.156535 PMC 바로가기 [Article Type] Article
Neutralizing activity to SARS-CoV-2 in 1.2 to 10.0 month convalescent plasma samples of COVID-19: A transversal surrogate in vitro study performed in Quito-EcuadorCOVID-19의 1.2~10.0개월 회복기 혈장 샘플에서 SARS-CoV-2에 대한 중화 활성: 키토-에콰도르에서 수행된 횡단 대리 시험관내 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyzed binding domain BSL2 facility BSL3 caused convalescence Convalescent patients convalescent plasma convalescent sera coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 determine diagnostic methods Ecuador glycoprotein IgG IgM Immunoglobulin Immunoglobulin G immunoglobulin M in some in vitro study Infection NAb NAbs neutralization test Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody performed plasma plasma. positive presence or absence Quito remained reported respiratory SARS-CoV-2 Seroconversion severe acute respiratory syndrome Coronavirus surrogate Test the SARS-CoV-2 Viral viral spike virus Wuhan Wuhan, China [DOI] 10.1002/jmv.27866 PMC 바로가기 [Article Type] Article
Poor Antibody Response to BioNTech/Pfizer Coronavirus Disease 2019 Vaccination in Severe Acute Respiratory Syndrome Coronavirus 2-Naive Residents of Nursing HomesBioNTech/Pfizer 코로나바이러스 질병 2019 중증 급성 호흡기 증후군 코로나바이러스 백신 접종에 대한 항체 반응 불량Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus administration age antibody Antibody Response B.1.351 B.1.351 variant Belgium binding antibodies binding antibody BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination Breakthrough infection cluster analysis comorbid conditions comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death detectable disease domain domains dose General population heterogeneity high risk home immunization Immunoglobulin immunosenescence IMPROVE in some Infection involved Messenger RNA mRNA mRNA vaccination mRNA vaccine Neutralizing Nursing nursing homes nursing homes. old age Poor RBD RBD IgG recruited related disease resident respiratory respond poorly Responder response S1 and S2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus Support the vaccine These data vaccination Vaccine vaccine strain variants variants of concern were assessed wild type [DOI] 10.1093/cid/ciab998 PMC 바로가기 [Article Type] Article
Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy임신 중 자간전증 및 COVID-19의 내피 및 혈관 신생 프로파일의 차이 및 유사성Article Published on 2022-08-012022-08-31 Journal: American journal of obstetrics and gynecology [Category] MERS, 바이오마커, 진단, [키워드] absence activate addition Adhesion Molecule alteration Analysis Angiogenesis angiogenic factors angiopoietin Antigen Biomarker Biomarkers C5b9 Cell cell membrane cell membranes Cell signaling change changes in circulating Coagulation Coagulopathy component Concentration Control controls COVID-19 COVID-19 infection COVID-19 patients Culture demonstrated difference differential diagnosis differentiation disease disorder endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction evaluated exhibited expected explained expression Extracellular Extracellular matrix group growth growth factor healthy heparan sulfate hypertensive hypertensive disorders of pregnancy Immunoblots immunofluorescence in some in vitro increase in Infection Inflammation inflammatory signaling innate immune response intercellular intercellular adhesion molecule less lysate lysates Mild mitogen-activated protein kinase Necrosis neutrophil Neutrophil extracellular trap Neutrophil extracellular traps normotensive overexpression Pathways Patient Phosphorylation placental placental growth factor preeclampsia Pregnancy pregnant women Principal component principal component analysis profile profiles Protein protein kinase receptor reduced reduction reduction in SARS-CoV-2 sera severe COVID-19 severe COVID-19 patient signaling pathway significant increase significantly increased Signs and symptoms similarity soluble fms-like tyrosine kinase-1 soluble tumor necrosis factor-α receptor I Spectrum statistical analysis statistically Study design sulfate Symptom Tumor tumor necrosis tumor necrosis factor-α tyrosine variable variance vascular cell adhesion von Willebrand disease von Willebrand factor von Willebrand factor. with COVID-19 women [DOI] 10.1016/j.ajog.2022.03.048 PMC 바로가기 [Article Type] Article
Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 micehACE2 마우스에서 항바이러스 식물화학물질에 의한 광범위한 SARS-CoV-2 변이체의 억제Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anti-inflammatory activity Antiviral antiviral activity antiviral drug antiviral drugs antiviral therapy attenuate Chlorella Chromatography Compound COVID-19 vaccines demonstrated Evolution Genetic Guava hACE2 host immune system in some in vivo inhibition Intervention mice new SARS-CoV-2 plant prevention of COVID-19 proinflammatory Prophylactics Psidium Region responses resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants significantly these compound these compounds Treatment Vaccine variant variants variants. viral clearance [DOI] 10.1016/j.antiviral.2022.105371 PMC 바로가기 [Article Type] Article